CVMFS on clusters
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LHC CVMFS examples contains information. The recommendation for clients 2.1 is _minimum_ 40 gigabytes of node-local cache.
Another source for information: https://www.gridpp.ac.uk/wiki/CVMFS_configuration_at_RAL
Each cluster should also have a HTTP proxy running, preferably Squid (+the AliMon cvmfs monitor). This machine needs ~20 gigabytes of memory, but 100 gigabytes of disk is enough. All files will be read from the cache anyway.
cvmfs-5.ndgf.org
cvmfs-5 has opened up the proxy to the jade cluster using DDR infiniband, allowing it to serve files at high speed.